


About Our Lab
Our research is currently modeling the stages of chronic kidney disease in the rodent model using non-invasive tracking of disease progression with advanced combinatorial imaging and understanding the stroke pathology in the presence of progressive CKD. Advances in understanding kidney-brain pathology is crucial to develop safe and effective stroke therapies. In the long term, our work aims at developing approaches to aid personalized stroke therapies for patients with existing risk factors.

Featured Publications
Kim T, Chelluboina B, Chokkalla AK, Vemuganti R. Age and sex differences in the pathophysiology of acute cns injury. Neurochem Int. 2019;127:22-28
Morris-Blanco KC, Kim T, Lopez MS, Bertogliat MJ, Chelluboina B, Vemuganti R. Induction of DNA hydroxymethylation protects the brain after stroke. 2019;50(9):2513-2521
Chelluboina B, Vemuganti R. Chronic kidney disease in the pathogenesis of acute ischemic stroke. J Cereb Blood Flow Metab. 2019:271678×19866733
Chokkalla A.K, Mehta S.L, Kim T, Chelluboina B, J.Y, Kim, Vemuganti R. Transient ischemia significantly alters m6A epitranscriptomic tagging of RNAs in the brain. Stroke. 2019;50(10):2912-2921.
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain
Chokkalla A.K, Mehta S.L, Kim T, Chelluboina B,Y, Kim, Vemuganti R. transient ischemia significantly alters m6A epitranscriptomic tagging of RNAs in the brain. Stroke. 2019;50(10):2912-2921
Chelluboina B, Kim T, Mehta S.L, Kim J-Y, Bathula S, Vemuganti R. Impact of Age and Sex on α-Syn (α-Synuclein) Knockdown-Mediated Poststroke Recovery. 2020; STROKEAHA120028978
Chelluboina B, Vemuganti R. Therapeutic potential of nutraceuticals to protect brain after stroke. Neurochem Int. 2021;142:104908
Nalamolu KR, Chelluboina B, Fornal CA, Challa SR, Pinson DM, Wang DZ, Klopfenstein JD, Veeravalli KK. Stem cell treatment improves post-stroke neurological outcomes: a comparative study in male and female rats. Stroke Vasc Neurol. 2021 [Epub ahead of print].
Mehta S.L, Morris-Blanco KC, Chokkalla A.K, Bathula S, Kim T, Chelluboina B, Holmes A, Banerjee A, Chauhan A, Lee J, Venna VR, McCullough, LD, Vemuganti R. Long noncoding RNA FosDT is critical for shaping the therapeutic post-stroke functional outcome. 2021; StrokeAHA120033547. PMID: 33940958