About Our Lab

Our research is currently modeling the stages of chronic kidney disease in the rodent model using non-invasive tracking of disease progression with advanced combinatorial imaging and understanding the stroke pathology in the presence of progressive CKD. Advances in understanding kidney-brain pathology is crucial to develop safe and effective stroke therapies. In the long term, our work aims at developing approaches to aid personalized stroke therapies for patients with existing risk factors.

Read More
Featured Publications

Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling

Jeong S, Chokkalla AK, Davis CK, Jeong H, Chelluboina B, Arruri V, Kim B, Narman A, Bathula S, Arumugam TV, Bendlin BB, Vemuganti R. Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling. Stroke. 2024 Jun 26. doi: 10.1161/STROKEAHA.124.046400. Epub ahead of print. PMID: 38920050.

Intermittent Fasting Induced Cerebral Ischemic Tolerance Altered Gut Microbiome and Increased Levels of Short-Chain Fatty Acids to a Beneficial Phenotype

Chelluboina B, Cho T, Park JS, Mehta SL, Bathula S, Jeong S, Vemuganti R. Intermittent Fasting Induced Cerebral Ischemic Tolerance Altered Gut Microbiome and Increased Levels of Short-Chain Fatty Acids to a Beneficial Phenotype. Neurochem Int. 2024 Jun 20:105795. doi: 10.1016/j.neuint.2024.105795. Epub ahead of print. PMID: 38908519.

Therapeutic Potential of Intravenous miR-21 Mimic after Stroke Following STAIR Criteria

Chelluboina B, Jeong S, Davis CK, Mehta SL, Vemuganti R. Therapeutic Potential of Intravenous miR-21 Mimic after Stroke Following STAIR Criteria. Transl Stroke Res. 2023 Dec 22. Epub ahead of print. PMID: 38129636.

Post-stroke brain can be protected by modulating the lncRNA FosDT

Mehta SL, Chelluboina B, Morris-Blanco KC, Bathula S, Jeong S, Arruri V, Davis CK, Vemuganti R. Post- stroke brain can be protected by modulating the lncRNA FosDT. J Cereb Blood Flow Metab. 2023 Nov 7:271678X231212378.

CDR1as regulates α- synuclein-mediated ischemic brain damage by controlling miR-7 availability

Mehta SL, Chokkalla AK, Bathula S, Arruri V, Chelluboina B, Vemuganti R. CDR1as regulates α- synuclein-mediated ischemic brain damage by controlling miR-7 availability. Mol Ther Nucleic Acids. 2022; 5; 31:57-67.

Tau and GSK-3β are Critical Contributors to α-Synuclein- Mediated Post-Stroke Brain Damage

Mehta SL, Kim T, Chelluboina B, Vemuganti R. Tau and GSK-3β are Critical Contributors to α-Synuclein- Mediated Post-Stroke Brain Damage. Neuromolecular Med. 2022; [Epub ahead of print].

MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice

Arruri V, Chokkalla AK, Jeong S, Chelluboina B, Mehta SL, Veeravalli KK, Vemuganti R. MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice. Neurochem Int. 2022

Gut virome dysbiosis following focal cerebral ischemia in mice

Chelluboina B, Kieft K, Breister A, Anantharaman K, Vemuganti R. Gut virome dysbiosis following focal cerebral ischemia in mice. Journal of Cerebral Blood Flow and Metabolism 2022; 14:271678X221107702.

Tenascin-C Induction Exacerbates Post-Stroke Brain Damage

Chelluboina B (corresponding author), Chokkalla A.K, Mehta S.L, Bathula S, Park JS, Vemuganti R. Tenascin-C Induction Exacerbates Post-Stroke Brain Damage. J Cereb Blood Flow Metab. 2021; 41 (11) 1–11

Featured

Long noncoding RNA FosDT is critical for shaping the therapeutic post-stroke functional outcome

Mehta S.L, Morris-Blanco KC, Chokkalla A.K, Bathula S, Kim T, Chelluboina B, Holmes A, Banerjee A, Chauhan A, Lee J, Venna VR, McCullough, LD, Vemuganti R. Long noncoding RNA FosDT is critical for shaping the therapeutic post-stroke functional outcome. 2021; StrokeAHA120033547. PMID: 33940958

Featured
View All

Featured News

Coming soon