Brain Diseases and Hypertension Management

Regulation of hypertension showed a crucial role in preventing the incidence/recurrence of stroke, and over a half of stroke survivors need a comprehensive long-term hypertension management plan with oral antihypertensives. The gut microbiome and oral antihypertensives have established interactive mechanisms that affect pharmacokinetics and dynamics. We investigate how post-stroke gut dysbiosis modulates the post-stroke hypertension management by mechanistic understanding of Gut-Drug interactions.